Factor VIII



Factor VIII (FVIII) is a blood clotting factor. Defects in the protein result in hemophilia A. FVIII is a cofactor for factor IXa. The images at the left and at the right correspond to one representative FVIII, i.e. the crystal structure of human Factor VIII (2r7e).

3D Structures of Factor VIII
2r7e, 3cdz – hFVIII – human

3hnb, 3hny, 3hob – hFVIII light chain C2 domain

1d7p - hFVIII light chain C2 domain (mutant)

1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR

1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab